Two childhood friends are separated after one’s family emigrates from South Korea. Two decades later, they are reunited in New York for one week as they confront notions of destiny, love and the choices that make a life.

After a gentle alien becomes stranded on Earth, the being is discovered and befriended by a young boy named Elliott. Bringing the extraterrestrial into his suburban California house, Elliott introduces E.T., as the alien is dubbed, to his brother and his little sister, Gertie, and the children decide to keep its existence a secret. Soon, however, E.T. falls ill, resulting in government intervention and a dire situation for both Elliott and the alien.

Mark and Mary's meet-cute happens at a neighborhood drug store, where she is busy buying a pregnancy test, and he has to make an effort to remind her they met in college. After asking her out, he accompanies her as she takes the test, and upon it showing negative, she agrees to a date. One year later, they have fallen deeply, passionately, head over heels in love, and their whirlwind romance leads to marriage. So when Mary suddenly requests they open their relationship to “ethical non-monogamy”, Mark is taken by surprise, but agrees to try it. And that's where this story really begins.

Actress Myrtle Gordon is a functioning alcoholic actress who is a few days from the opening night of her latest play, concerning a woman distraught about aging. One night a car kills one of Myrtle's fans who is chasing her limousine in an attempt to get the star's attention. Myrtle internalizes the accident and goes on a spiritual quest, but fails to finds the answers she is after. As opening night inches closer and closer, fragile Myrtle must find a way to make the show go on.

David, a struggling comedy writer fresh off from breaking up with his boyfriend, moves from New York City to Sacramento to help his sick mother. Living with his conservative father and much-younger sisters for the first time in ten years, he feels like a stranger in his childhood home. As his mother’s health declines, David frantically tries to extract meaning from this horrible experience and convince everyone (including himself) that he's "doing okay.”