Buenos Aires is Argentina’s big, cosmopolitan capital city. Its center is the Plaza de Mayo, lined with stately 19th-century buildings including Casa Rosada, the iconic, balconied presidential palace. Other major attractions include Teatro Colón, a grand 1908 opera house with nearly 2,500 seats, and the modern MALBA museum, displaying Latin American art.

New York City comprises 5 boroughs sitting where the Hudson River meets the Atlantic Ocean. At its core is Manhattan, a densely populated borough that’s among the world’s major commercial, financial and cultural centers. Its iconic sites include skyscrapers such as the Empire State Building and sprawling Central Park. Broadway theater is staged in neon-lit Times Square.

Paris, France's capital, is a major European city and a global center for art, fashion, gastronomy and culture. Its 19th-century cityscape is crisscrossed by wide boulevards and the River Seine. Beyond such landmarks as the Eiffel Tower and the 12th-century, Gothic Notre-Dame cathedral, the city is known for its cafe culture and designer boutiques along the Rue du Faubourg Saint-Honoré.

Prague, capital city of the Czech Republic, is bisected by the Vltava River. Nicknamed “the City of a Hundred Spires,” it's known for its Old Town Square, the heart of its historic core, with colorful baroque buildings, Gothic churches and the medieval Astronomical Clock, which gives an animated hourly show.

New Orleans is a Louisiana city on the Mississippi River, near the Gulf of Mexico. Nicknamed the "Big Easy," it's known for its round-the-clock nightlife, vibrant live-music scene and spicy, singular cuisine reflecting its history as a melting pot of French, African and American cultures.