This newsmagazine series investigates intriguing crime and justice cases that touch on all aspects of the human experience. Over its long run, the show has helped exonerate wrongly convicted people, driven the reopening — and resolution — of cold cases, and changed numerous lives. CBS News correspondents offer an in-depth look into each story, with the emphasis on solving the mystery at its heart.

Follows the misadventures of four irreverent grade-schoolers in the quiet, dysfunctional town of South Park, Colorado.

Set in Springfield, the average American town, the show focuses on the antics and everyday adventures of the Simpson family; Homer, Marge, Bart, Lisa and Maggie, as well as a virtual cast of thousands. Since the beginning, the series has been a pop culture icon, attracting hundreds of celebrities to guest star. The show has also made name for itself in its fearless satirical take on politics, media and American life in general.