Marcus Burnett is a hen-pecked family man. Mike Lowry is a foot-loose and fancy free ladies' man. Both are Miami policemen, and both have 72 hours to reclaim a consignment of drugs stolen from under their station's nose. To complicate matters, in order to get the assistance of the sole witness to a murder, they have to pretend to be each other.

Out-of-control, trash-talking buddy cops Marcus Burnett and Mike Lowrey of the Miami Narcotics Task Force reunite, and bullets fly, cars crash and laughs explode as they pursue a whacked-out drug lord from the streets of Miami to the barrios of Cuba. But the real fireworks result when Marcus discovers that playboy Mike is secretly romancing Marcus’ sexy sister.