The misadventures of a group of friends as they navigate the pitfalls of work, life and love in Manhattan.

Into every generation a slayer is born: one girl in all the world, a chosen one. She alone will wield the strength and skill to fight the vampires, demons, and the forces of darkness; to stop the spread of their evil and the swell of their number. She is the Slayer.

Three sisters (Prue, Piper and Phoebe) reunite and unlock their powers to become the Charmed Ones, the most powerful good witches of all time, whose prophesied destiny is to protect innocent lives from evil beings such as demons and warlocks. Each sister possesses unique magical powers that grow and evolve, while they attempt to maintain normal lives in modern day San Francisco.