Rick is a mentally-unbalanced but scientifically-gifted old man who has recently reconnected with his family. He spends most of his time involving his young grandson Morty in dangerous, outlandish adventures throughout space and alternate universes. Compounded with Morty's already unstable family life, these events cause Morty much distress at home and school.

Set in Springfield, the average American town, the show focuses on the antics and everyday adventures of the Simpson family; Homer, Marge, Bart, Lisa and Maggie, as well as a virtual cast of thousands. Since the beginning, the series has been a pop culture icon, attracting hundreds of celebrities to guest star. The show has also made name for itself in its fearless satirical take on politics, media and American life in general.