Tomozaki is one of the best gamers in Japan, and in his opinion, the game of real life is one of the worst. No clear-cut rules for success, horribly balanced, and nothing makes sense. But then he meets a gamer who’s just as good as him, and she offers to teach him a few exploits…

Moriko Morioka is a 30-year-old single NEET woman. After dropping out from reality, she has taken off in search for a fulfilling life and ended up in a net game or "netoge." In the netoge world, she began her new life as a refreshing and handsome character named Hayashi. While starting out as a beginner, a pretty character named Lily reached out to help her. Meanwhile, in the real world, awaits a shocking encounter with a good-looking elite company employee, a mysterious blue-eyed blonde.

Sorata Kanda, a high school sophomore living in Sakurasou, the den of their academy's problem children, spends his days being dragged around by the strange residents, swearing he's going to escape Sakurasou one day.

Arata Kaizaki (27) quit the job he landed after graduation in only three months. His life did not go well after that. Now his parents are threatening to stop sending money, and want him to come back to the country. He has no friend or girlfriend to share his troubles with...as he hits rock bottom a strange man named Ryou Yoake appears. He invites Arata to join a societal rehabilitation program for NEETs called ReLife. This program uses a mysterious drug to make him look younger, and sends him back to high school for a year...

Set six years prior to the events of Barakamon, detailing the life of Seishuu Handa as a high school student—and a very interesting life it is. In Handa-kun, Seishuu Handa is admired by his peers as a calligraphy genius and given the utmost respect, but Handa-kun himself is under the mistaken impression that the deference and attention he receives from the other students is actually bullying. Handa just wants to live a quiet life, but hilarity ensues as one character after another challenges his position as the school idol, and somehow comes away as a fan all while Handa is horrified and clueless.

Hitori Bocchi suffers from extreme social anxiety, she's not good at talking to people, takes pretty extreme actions, is surprisingly adept at avoiding people, her legs cramp when she overexerts herself, gets full of herself when alone, will vomit when exposed to extreme tension and often comes up with plans. Now she is entering middle school and her only friend, Yawara Kai, is attending a different school. This leaves Bocchi alone, surrounded by new classmates with whom she must make friends before Kai will talk to her again.

At a high school full of unique characters, Tadano helps his shy and unsociable classmate Komi reach her goal of making friends with 100 people.