Guts, a man who calls himself "The Black Swordsman", looks back upon his days serving as a member of a group of mercenaries. Led by an ambitious, ruthless, and intelligent man named Griffith, together they battle their way into the royal court, and are forced into a fate that changes their lives.

The Sakuragoaka Girls' Academy curriculum traditionally focuses on the three "R"s of reading, writing and arithmetic, but Ritsu Tainaka wants to add two more "R"s: Rock and Roll! To do that, however, Ritsu has to save the Light Music Club from being shut down due to little problems like not having any other members or a faculty advisor. After strong-arming her best friend Mio into joining and convincing Tsumugi Kotobuki to make it a trio, Ritsu's would-be rockers are soon only one talented guitarist short of the quartet they need for school approval. What they get, unfortunately, is Yui Hirasawa, who's never held a guitar in her life, but she's determined to learn! Will the school halls come alive with the sound of music?

In 2071, roughly fifty years after an accident with a hyperspace gateway made the Earth almost uninhabitable, humanity has colonized most of the rocky planets and moons of the Solar System. Amid a rising crime rate, the Inter Solar System Police (ISSP) set up a legalized contract system, in which registered bounty hunters (also referred to as "Cowboys") chase criminals and bring them in alive in return for a reward.

Mugen is a ferocious, animalistic warrior with a fighting style inspired by break-dancing. Jin is a ronin samurai who wanders the countryside alone. They may not be friends, but their paths continually cross. And when ditzy waitress Fuu gets them out of hot water with the local magistrate, they agree to join her search for the "samurai who smells of sunflowers."

A great warrior is displaced to the distant future by the evil shape-shifting wizard Aku. The world has become a bleak place under the rule of Aku, segregated into fantastic tribes and ruled by Aku's evil robot warlords. Jack travels this foreign landscape in search of a time portal that can return him to his home time so he can "undo the future that is Aku!".