Dr. Gregory House, a drug-addicted, unconventional, misanthropic medical genius, leads a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital in New Jersey.

The Doctor is a Time Lord: a 900 year old alien with 2 hearts, part of a gifted civilization who mastered time travel. The Doctor saves planets for a living—more of a hobby actually, and the Doctor's very, very good at it.

The sitcom is centered on five characters living in Pasadena, California: roommates Leonard Hofstadter and Sheldon Cooper; Penny, a waitress and aspiring actress who lives across the hall; and Leonard and Sheldon's equally geeky and socially awkward friends and co-workers, mechanical engineer Howard Wolowitz and astrophysicist Raj Koothrappali. The geekiness and intellect of the four guys is contrasted for comic effect with Penny's social skills and common sense.

In Tree Hill, North Carolina two half brothers share a last name and nothing else. Brooding, blue-collar Lucas is a talented street-side basketball player, but his skills are appreciated only by his friends at the river court. Popular, affluent Nathan basks in the hero-worship of the town, as the star of his high school team. And both boys are the son of former college ball player Dan Scott whose long ago choice to abandon Lucas and his mother Karen, will haunt him long into his life with wife Deb and their son Nathan.