Stuart, an adorable white mouse, still lives happily with his adoptive family, the Littles, on the east side of Manhattan's Central Park. More crazy mouse adventures are in store as Stuart, his human brother, George, and their mischievous cat, Snowbell, set out to rescue a friend.

The adventures of a heroic and debonair stalwart mouse named Stuart Little with human qualities, who faces some comic misadventures while searching for his lost bird friend and living with a human family as their child.