Guts, a man who calls himself "The Black Swordsman", looks back upon his days serving as a member of a group of mercenaries. Led by an ambitious, ruthless, and intelligent man named Griffith, together they battle their way into the royal court, and are forced into a fate that changes their lives.

At the beginning of the Edo Era, when people enjoyed a time of peace, Lord Tokugawa Tadanaga holds a fighting tournament. In the past, matches were fought with wooden swords. This time, real swords will be used. One-armed Fujiki Gennosuke and blind Irako Seigen will fight each other in this match. Both are disciples of Iwamoto Kogan, who is known as Japan's greatest swordsman. Each of them are determined to prove himself the successor of Iwamoto's school. However, there can only be one champion. So begins a story of intertwining fates, conflict, and strange destinies.

In a futuristic Japan where conflicts are settled by the sword, Afro Samurai must avenge his father's murder by challenging a powerful warrior.

Fourteen years after defeating the immortal warrior Himuro Genma and thwarting the Shogun of the Dark's evil plans, Kibagami Jubei continues to roam all over Japan as a masterless swordsman. During his journey, he meets Shigure, a priestess who has never seen the world outside her village. But when a group of demons destroys the village and kills everyone, Jubei becomes a prime target after acquiring the Dragon Jewel — a stone with an unknown origin. Meanwhile, Shigure — along with the monk Dakuan and a young thief named Tsubute — travels to the village of Yagyu. And with two demon clans now hunting down Shigure, Dakuan must once again acquire the services of Jubei to protect the Priestess of Light.

Mugen is a ferocious, animalistic warrior with a fighting style inspired by break-dancing. Jin is a ronin samurai who wanders the countryside alone. They may not be friends, but their paths continually cross. And when ditzy waitress Fuu gets them out of hot water with the local magistrate, they agree to join her search for the "samurai who smells of sunflowers."

In 2071, roughly fifty years after an accident with a hyperspace gateway made the Earth almost uninhabitable, humanity has colonized most of the rocky planets and moons of the Solar System. Amid a rising crime rate, the Inter Solar System Police (ISSP) set up a legalized contract system, in which registered bounty hunters (also referred to as "Cowboys") chase criminals and bring them in alive in return for a reward.