Vignettes weaving together the stories of six individuals in the old West at the end of the Civil War. Following the tales of a sharp-shooting songster, a wannabe bank robber, two weary traveling performers, a lone gold prospector, a woman traveling the West to an uncertain future, and a motley crew of strangers undertaking a carriage ride.

Llewelyn Moss stumbles upon dead bodies, $2 million and a hoard of heroin in a Texas desert, but methodical killer Anton Chigurh comes looking for it, with local sheriff Ed Tom Bell hot on his trail. The roles of prey and predator blur as the violent pursuit of money and justice collide.

During a shootout in a saloon, Sheriff Hunt injures a suspicious stranger. The doctor's assistant, wife of the local foreman, tends to him in prison. That night, the town is attacked and they both disappear—only the arrow of a cannibal tribe is found. Hunt and a few of his men go in search of the prisoner and the foreman's wife.

A Texas Ranger investigates a series of unexplained deaths in a town called Helena.

After a violent encounter, Roy finds Rocky and sees something in her eyes that prompts a fateful decision. He takes her with him as he flees to Galveston, an action as ill-advised as it is inescapable.

A legendary Native American-hating Army captain nearing retirement in 1892 is given one last assignment: to escort a Cheyenne chief and his family through dangerous territory back to his Montana reservation.

Oregon, 1851. Hermann Kermit Warm, a chemist and aspiring gold prospector, keeps a profitable secret that the Commodore wants to know, so he sends the Sisters brothers, two notorious assassins, to capture him on his way to California.

With the help of a German bounty hunter, a freed slave sets out to rescue his wife from a brutal Mississippi plantation owner.

In the 1820s, a frontiersman, Hugh Glass, sets out on a path of vengeance against those who left him for dead after a bear mauling.

Bounty hunters seek shelter from a raging blizzard and get caught up in a plot of betrayal and deception.

Seth Gecko and his younger brother Richard are on the run after a bloody bank robbery in Texas. They escape across the border into Mexico and will be home-free the next morning, when they pay off the local kingpin. They just have to survive 'from dusk till dawn' at the rendezvous point, which turns out to be a Hell of a strip joint.

In the menacing inferno of the old North-American West, Liz is a genuine survivor who is hunted by a vengeful preacher for a crime she didn’t commit.