Stephanie, a dedicated mother and popular vlogger, befriends Emily, a mysterious upper-class woman whose son Nicky attends the same school as Miles, Stephanie's son. When Emily asks her to pick Nicky up from school and then disappears, Stephanie undertakes an investigation that will dive deep into Emily's cloudy past.

Clarice Starling is a top student at the FBI's training academy. Jack Crawford wants Clarice to interview Dr. Hannibal Lecter, a brilliant psychiatrist who is also a violent psychopath, serving life behind bars for various acts of murder and cannibalism. Crawford believes that Lecter may have insight into a case and that Starling, as an attractive young woman, may be just the bait to draw him out.

Rachel Watson, devastated by her recent divorce, spends her daily commute fantasizing about the seemingly perfect couple who live in a house that her train passes every day, until one morning she sees something shocking happen there and becomes entangled in the mystery that unfolds.

The true story of the investigation of the "Zodiac Killer", a serial killer who terrified the San Francisco Bay Area, taunting police with his ciphers and letters. The case becomes an obsession for three men as their lives and careers are built and destroyed by the endless trail of clues.