A modern update finds the famous sleuth and his doctor partner solving crime in 21st century London.

The early life of child genius Sheldon Cooper, later seen in The Big Bang Theory.

The sitcom is centered on five characters living in Pasadena, California: roommates Leonard Hofstadter and Sheldon Cooper; Penny, a waitress and aspiring actress who lives across the hall; and Leonard and Sheldon's equally geeky and socially awkward friends and co-workers, mechanical engineer Howard Wolowitz and astrophysicist Raj Koothrappali. The geekiness and intellect of the four guys is contrasted for comic effect with Penny's social skills and common sense.

The Doctor is a Time Lord: a 900 year old alien with 2 hearts, part of a gifted civilization who mastered time travel. The Doctor saves planets for a living—more of a hobby actually, and the Doctor's very, very good at it.

The adventures of a Time Lord—a time-travelling humanoid alien known as the Doctor—who explores the universe in his TARDIS, a sentient time-travelling space ship. Its exterior appears as a blue British police box, which was a common sight in Britain in 1963 when the series first aired. Along with a succession of companions, the Doctor faces a variety of foes while working to save civilisations, help ordinary people, and right wrongs.