Following the events of Captain America: Civil War, Peter Parker, with the help of his mentor Tony Stark, tries to balance his life as an ordinary high school student in Queens, New York City, with fighting crime as his superhero alter ego Spider-Man as a new threat, the Vulture, emerges.

Miles Morales is juggling his life between being a high school student and being a spider-man. When Wilson "Kingpin" Fisk uses a super collider, others from across the Spider-Verse are transported to this dimension.