By exploring common themes in the lives and works of logician Kurt Gödel, artist M. C. Escher, and composer Johann Sebastian Bach, the book expounds concepts fundamental to mathematics, symmetry, and intelligence. Through short stories, illustrations, and analysis, the book discusses how systems can acquire meaningful context despite being made of "meaningless" elements. It also discusses self-reference and formal rules, isomorphism, what it means to communicate, how knowledge can be represented and stored, the methods and limitations of symbolic representation, and even the fundamental notion of "meaning" itself.