The series follows the main "ghoulfriends" (girlfriends) of the franchise such as Frankie Stein, Clawdeen Wolf, Draculaura, Lagoona Blue, Cleo de Nile, Ghoulia Yelps, and Abbey Bominable; and how they manage in the "Monster High" high school. Other characters appear throughout the series, such as the antagonist Toralei Stripe (a were-cat).