The tale of three mothers of first graders whose apparently perfect lives unravel to the point of murder.

When a young boy vanishes, a small town uncovers a mystery involving secret experiments, terrifying supernatural forces, and one strange little girl.

It’s 1958 Manhattan and Miriam “Midge” Maisel has everything she’s ever wanted - the perfect husband, kids, and Upper West Side apartment. But when her life suddenly takes a turn and Midge must start over, she discovers a previously unknown talent - one that will take her all the way from the comedy clubs of Greenwich Village to a spot on Johnny Carson’s couch.

Inexperienced Otis channels his sex therapist mom when he teams up with rebellious Maeve to set up an underground sex therapy clinic at school.