The sitcom is centered on five characters living in Pasadena, California: roommates Leonard Hofstadter and Sheldon Cooper; Penny, a waitress and aspiring actress who lives across the hall; and Leonard and Sheldon's equally geeky and socially awkward friends and co-workers, mechanical engineer Howard Wolowitz and astrophysicist Raj Koothrappali. The geekiness and intellect of the four guys is contrasted for comic effect with Penny's social skills and common sense.

Comedy about one big happy family and their sometimes awkward, often hilarious and ultimately beautiful milestone moments as told by its various members. Of the three siblings, middle child Matt may have just found his true love, his co-worker, Colleen; his coddled youngest brother, Greg, and his wife, Jen, are overwhelmed by the birth of their first child; and the eldest, Heather, and her husband, Tim, are dreading their impending empty nest so much, they're considering having another baby. Their parents are Joan the family's adoring matriarch who would do anything for her kids - as long as she agrees with it - and John, the gregarious patriarch who's searching for ways to soften the blow of turning 70. As the family's lives unfold in four short stories each week, they try to savor these little pieces of time that flash by but stay with you forever, because these moments add up to what life's all about.

A comedy about a working class Chicago couple who find love at an Overeaters Anonymous meeting.

Jules Cobb is a mom in her forties facing the often humorous challenges, pitfalls and rewards of life's next chapter. Along for the journey is her son, her ex-husband, her husband/neighbor and her friends who together make up her dysfunctional, but supportive and caring extended family... even if they have a funny way of showing it sometimes.

The early life of child genius Sheldon Cooper, later seen in The Big Bang Theory.

After dropping everything to make the move from skyscrapers to farmhouses, Rio and Mike soon realize that the simpler life isn't as easy as they planned.

In the unreal world of Sacred Heart Hospital, John "J.D." Dorian learns the ways of medicine, friendship and life.

A father recounts to his children - through a series of flashbacks - the journey he and his four best friends took leading up to him meeting their mother.

The daily mishaps of a married woman and her semi-dysfunctional family and their attempts to survive life in general in the city of Orson, Indiana.